Yesterday researchers announced that they have identified seven gene regions linked to causing coeliac disease.
Also the research found that four of these gene regions are responsible for a predisposition to Type 1 diabetes (the type which occurs from birth), indicating that these discoveries may have broad implications for a range of inflammatory or autoimmune diseases.
Previous studies identified a genetic region on chromosome four associated with coeliac disease. In this study, the same research group identified seven new genetic regions associated with an increased risk of coeliac disease. They compared genetic markers in people with and without coeliac disease and then assessed about 1,000 of the strongest markers in a further 5,000 samples.
The results, published in Nature Genetics (Hunt, K. Nature Genetics, March 2, 2008), identified seven new genetic risk regions associated with celiac disease. Of those seven mutations, six involve genes that control immune responses (four of these, presumably, being the diabetic-type response).
The research team included collaborators from Ireland, the Netherlands, and the Wellcome Trust Sanger Institute, and was led by David van Heel, Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry.
Professor van Heel said: “So far our findings explain nearly half of the heritability of coeliac disease – now studies with many more samples from individuals with coeliac disease are needed to identify the precise causal genetic variants from each region, and understand how these influence biological processes.”
Does this mean we may be a step closer to a solution?
We already know that coeliac disease and diabetes are linked – and that people with some other auto-immune problems may be helped with a gluten free diet. It’s good to have scientific confirmation of […]